The vast majority of cancer patients never realize they might have cancer until something goes wrong with their health as the current diagnostic methods for other cancers are invasive and expensive. In many cases it gets already too late by the point cancer is detected. Early detection of cancer is one of the prerequisites for better treatment of cancer, say doctors.
To eliminate this problem and making cancer detection easy and affordable and enable checking for dozens of cancers using a single blood sample, Miroculus, a new start up, is developing a new device. This low-cost, open source device made its public debut a year ago at the TEDGlobal conference in Rio De Janeiro and is known as Miriam.
The founder of the company comprise of a global team of entrepreneurs, microbiologists, and data scientists. The company intends to develop the apparatus in such a way that it remains very simple so that even untrained workers in clinics around the world could use it with ease and with accuracy. Despite the project being in the early stages, preliminary reports suggest that the cancer detection process would be as simple as getting blood drawn.
The operational dynamics of the new under construction device works on detection of microRNA. This is a class of small molecules that can act as a type of biological warning sign. Based on what is happening in our bodies at that moment these molecules appear and disappear. This is the reason that ever since they were first discovered in 1993, these molecules have become effective indicators of diseases including cancer. Trhe micorRNA would be able to identify the specific type of cancer that person might have apart from revealing whether a person may have cancer or not.
Researchers in earlier years were inclined to believe that microRNA could only be found inside of cells, making these biomarkers less accessible. It was only s late as 2008, the a group of scientists discovered microRNA circulating in blood. This was a cue for greater interest in the molecule as it was known that microRNA was the key to early cancer detection.
The new device wants to utilize and capitalize on the already known property of microRNA and its ability to signal cancer. Using a standard off-the-shelf RNA extraction kit, as well as a Miroculus “master mix”, one can prepare the blood sample. Miroculus “master mix” I another means of preparing the raw sample for the test. The prepared blood sample is then pipette into a 96-well plate in the new device.
This well plate is pre treated to with a patented biochemistry to function as a trap to collect microRNA that are most commonly associated with cancer.
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